Human Genes Linked with Cigarette Smoking

Published on April 29th, 2010 09:28

Quitting smoking is not so easy for some smokers. Till now many studies showed that those smokers who have not enough desire could not kick the bad habit. But a recent study found that for some people, quitting smoking could be difficult because of their genes.

Researchers found that three genetic sections that were binned with the number of cigarettes smoked per day.

genes connected whit smoking

Helena Furberg, a research assistant professor at the University of North Carolina, explained: “One section was connected with smoking beginning, and another variant was associated with smoking cessation. The genetic variants on chromosome 15 that were linked with heavy smoking lie inside a region that contains nicotine receptor genes, which other scientists have beforehand linked with nicotine addiction and lung cancer.”

Researchers analyzed of the phenotypes (any remarkable characteristic of an organism) of 74,053 people, and encouraged them to quit smoking. Furberg reported that is needed for much more investigations and time before these findings can be transferred to the clinic: “At this moment, getting tested for this version will not tell you anything important about your risk of smoking or ability to quit smoking cigarettes”.

But in the future, researchers should be capable to use these genetic versions for to forecast the results of unusual smoking cessation treatments. Another team of researchers conducted by Clyde Francks from Oxford University investigated the human genes in 40,000 people linked with cigarette smoking.

At the end of investigation they found that a group of genes on chromosome 15q25 is linked with the amount of cigarettes that people smoke every day.

“Comprehending the genetics of smoking addiction will be a very important finding for worldwide people,” Francks declared.

Another study, the third one conducted researchers from Iceland, also investigated the human genome among 70,000 smokers for o find genes bound with the number of cigarettes a smoker smokes per day. They found that genes on chromosome among 15 years old smokers were linked to tobacco use. The researchers also discovered two more genes, CYP2A6 and CYP2B6 that were included in nicotine metabolism and two others, CHRNB3 and CHRNA6 that played a role in how the human body processes nicotine.

Some of these gene regions are also linked with an inclination to lung cancer, the researchers observed.

Dr. Norman H. Edelman, scientific counselor to the American Lung Association, said that the new information found by the study “adds to the immediate restricted data demonstrating that favor to smoking has some genetic elements.”

By Joanna Johnson, Staff Writer. Copyright © 2010 All rights reserved.

Related tags: smokers | smoking | cigarettes | smoke | nicotine addiction

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